61. First two weeks on meds
Many people do not feel "fixed" on day one. Some feel nothing for a fortnight. A few feel jittery. Some describe a sudden calm. This page covers what is normal, what isn't, and when to call your prescriber.
Often normal · Days 1-3: The first few days
+A bit of jitteriness, reduced appetite, a low-grade headache or a slightly dry mouth are all common. Some people describe a subtle "the noise in my head is quieter" feeling, and some people feel nothing at all, which is also fine, the starting dose is deliberately low.
Often normal · Days 4-14: The settling-in fortnight
+For many people, side effects start to settle within a few weeks. Tell your prescriber if they don't. Many people only notice real change after the second or third dose increase, because titration is a six to twelve week process, not a switch you flick on day one.
Worth a call: Ring your prescriber if
+Call your prescriber if you have a racing heart or chest pain, severe anxiety or panic that won't ease, a big drop in mood as the dose wears off, very poor sleep for more than five nights, or you cannot eat at all. This does not necessarily mean medication is not for you. Your prescriber may suggest a different dose or medicine.
What often helps: A few practical anchors
+Try to take your meds at roughly the same time every day, and eat something protein-heavy first, otherwise your appetite will not return until 7pm. Keep a water bottle in arm's reach, stimulants are diuretic. And note daily one-to-ten ratings of focus, mood and sleep, your prescriber will ask about these at your next review.
This page provides general information and is not medical advice. Speak to a qualified clinician or prescriber about diagnosis, treatment or medication changes. Last checked September 2026.